Norleucine, D-(-)- → Hexanoic acid, 2-hydroxy-, (2R)-
反応式
N[C@@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH2:4][CH2:5][CH3:6].N([O-])=[O:11].[Na+]>S(=O)(=O)(O)O.O>[OH:11][C@H:2]([CH2:3][CH2:4][CH2:5][CH3:6])[C:7]([OH:9])=[O:8]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a cooled (0° C.), stirred solution of D-norleucine (500 mg, 3.81 mmol) in 10 mL of 1N aqueous sulfuric acid was added sodium nitrite (421 mg, 6.10 mmol) in 3 mL of water dropwise over a 20-minute period. The reaction mixture was allowed to slowly warm to room temperature over a 16-hour period. The mixture then was extracted with EtOAc (2×25 mL), dried (Na2SO4), and concentrated to yield 200 mg (40%) of a white waxy solid.
後処理
- temperatureto slowly warm to room temperature over a 16-hour period
- extractionThe mixture then was extracted with EtOAc (2×25 mL)
- dry with materialdried (Na2SO4)
- concentrationconcentrated
- customto yield 200 mg (40%) of a white waxy solid
出典と根拠
- ORDレコード
- ord-096116ff309044bc94fcf8e4c97ecdf1
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06423710B1
反応ノート
読み込み中…