Water → 1-Acenaphtheneacetic acid

HRID 2230266ノート

反応式

HRID 2230266 の反応式
C([O:3][C:4](=[O:18])[CH2:5][CH:6]1[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH:11]=[CH:10][CH:9]=[C:8]3[CH2:7]1)C.[OH-].[K+].O>CO>[CH:6]1([CH2:5][C:4]([OH:18])=[O:3])[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH:11]=[CH:10][CH:9]=[C:8]3[CH2:7]1

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 13715672Ethyl2-(1,2-dihydro-1-acenaphthylenyl)acetate

生成物 1

HCID 3445191-Acenaphtheneacetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The ester obtained in Step C (1.9 g, 7.91.10−3 mol) is heated at reflux in the presence of potassium hydroxide (2.34 g, 4.17.10−2 mol, 5.3 eq.), water (16 ml) and methanol (16 ml) for one night. After evaporating off the solvent, the residue is taken up in water and extracted twice with ether. The basic aqueous phase is acidified using concentrated HCl in the cold state. The acid is extracted with ethyl acetate and dried over MgSO4. After evaporating off the solvent under reduced pressure, the title compound is obtained in the form of a yellow solid.

後処理

  1. customAfter evaporating off the solvent
  2. extractionextracted twice with ether
  3. extractionThe acid is extracted with ethyl acetate
  4. dry with materialdried over MgSO4
  5. customAfter evaporating off the solvent under reduced pressure

出典と根拠

ORDレコード
ord-05a60df93b1e44c8a9252e7aa4a4a5a4
出典データセット
uspto-grants-2002_07
特許番号
US06423870B1

反応ノート

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