化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl acetamidate hydrochloride → HCID 131723418、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl acetamidate hydrochloride | HCID 19983589 | — |
| 反応物 | 4-(3-(4-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridine | HCID 22037479 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 131723418 | HCID 131723418 | — |
反応手順
To a suspension of 5-(4-piperidyl)-4-(4-pyridyl)-3-(4-fluorophenyl)pyrazole (Example C-2) (0.11 g, 0.35 mmol) in 2 mL EtOH was added ethyl acetamidate hydrochloride (0.065 g, 0.53 mmol) and the mixture was refluxed for 30 minutes. The solution was left at 5-10° C. for 16 h and filtered to obtain the title compound as a white solid: MS (M+H): 364 (base peak).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06423713B1 |
| 出典データセット | uspto-grants-2002_07 |
| ORD ID | ord-7221527b57da424dade102d6b22d56bf |
| 出典メモ | uspto-grants-2002_07 |