2-Oxo-3-benzoylamino-5-acetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid → (3S)-2-Oxo-3-(3,5-dichloro4-hydroxybenzoyl)amino-5-hydroxyacetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide
反応式
C(OC(=O)CN1C2C=CC=CC=2NC[C@H](NC(OC(C)(C)C)=O)C1=O)C1C=CC=CC=1.O=C1N(CC(O)=O)C2C=CC=CC=2N(C(=O)C)CC1NC(=O)C1C=CC=CC=1.[O:60]=[C:61]1[N:67]([CH2:68][C:69]([NH:71][C@H:72]2[CH2:76][C:75](=[O:77])[O:74][CH:73]2[O:78][CH2:79][C:80]2[CH:85]=[CH:84][CH:83]=[CH:82][CH:81]=2)=[O:70])[C:66]2[CH:86]=[CH:87][CH:88]=[CH:89][C:65]=2[N:64]([C:90](=[O:94])[CH2:91][O:92]C)[CH2:63][C@@H:62]1[NH:95][C:96](=[O:106])[C:97]1[CH:102]=[C:101]([Cl:103])[C:100]([OH:104])=[C:99]([Cl:105])[CH:98]=1>>[O:60]=[C:61]1[N:67]([CH2:68][C:69]([NH:71][C@H:72]2[CH2:76][C:75](=[O:77])[O:74][CH:73]2[O:78][CH2:79][C:80]2[CH:81]=[CH:82][CH:83]=[CH:84][CH:85]=2)=[O:70])[C:66]2[CH:86]=[CH:87][CH:88]=[CH:89][C:65]=2[N:64]([C:90](=[O:94])[CH2:91][OH:92])[CH2:63][C@@H:62]1[NH:95][C:96](=[O:106])[C:97]1[CH:98]=[C:99]([Cl:105])[C:100]([OH:104])=[C:101]([Cl:103])[CH:102]=1参加物
4
反応物 3
HCID 184657172-Oxo-3-benzoylamino-5-acetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid
HCID 22954562(3S)-2-Oxo-3-(3,5-dichloro-4-hydroxybenzoyl)amino-5-methoxyacetyl-N-[(2RS,3S)-benzyloxy-5-oxo-tetrahydrofuran-3-yl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetamide
HCID 57313411HCID 57313411、化合物2 回生成物 1
実験手順
was synthesized from 600b via methods used to prepare 661 from 600b, excluding steps used to make 604d from 603d, using instead the method to prepare 688a from 678a to afford 854 mg of 692a, 1H NMR (CD3OD) δ2.45(d, 1H), 2.6(m, 1H), 2.7(m, 1H), 3.0(m, 1H), 3.5-3.7(m, 4H), 4.0(q, 2H), 4.45(m,3H), 4.55(m, 4H), 5.35(s, 1H), 5.6(d, 1H), 7.2-7.5(m, 9H), 7.85(s, 2H).
出典と根拠
- ORDレコード
- ord-a9bcb6c6e03542a0b6f3147e64202e7b
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06423840B1
反応ノート
読み込み中…