Hydrochloric Acid → 2-Methoxy-5-methYlsulfinylbenzoic acid
反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:15])=[O:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[K+].Cl>ClCCl>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:15])=[O:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]参加物
5
実験手順
Combine methyl 2-methoxy-5-methylsulfinylbenzoate (2.37 g, 12.0 mmol) and a 1 M aqueous solution of potassium hydroxide (13 mL, 13 mmol). Heat to reflux. After 2 hours, cool to ambient temperature and adjust the pH to about 2 using a 1 M aqueous hydrochloric acid (14.5 mL, 14.5 mmol). Evaporate in vacuo to give a solid. Combine the solid and dichloromethane and stir. Decant the solvent and add more dicliloromethane. Again decant and combine with the first decantate, dry over Na2SO4, filter, and evaporate in vacuo to to give the title compound: mp; 114-116° C.
後処理
- temperatureHeat to reflux
- customEvaporate in vacuo
- customto give a solid
- customDecant the solvent
- additionadd more dicliloromethane
- customAgain decant
- dry with materialdry over Na2SO4
- filtrationfilter
- customevaporate in vacuo
出典と根拠
- ORDレコード
- ord-3bc802bb233041aabd0107d7db0ff7b3
- 出典データセット
- uspto-grants-2002_07
- 特許番号
- US06423704B1
反応ノート
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