Water → HCID 21286378、化合物

HRID 2231188ノート

反応式

HRID 2231188 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:20]2[C:25](=[O:26])[NH:24][C:23](=[O:27])[CH2:22][NH:21]2)[CH:5]=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][CH:10]=1.S(=O)(=O)(O)O.O.[C:34](OC(=O)C)(=[O:36])[CH3:35]>>[C:34]([N:21]1[CH2:22][C:23](=[O:27])[NH:24][C:25](=[O:26])[N:20]1[C:4]1[CH:5]=[C:6]([Cl:19])[C:7]([O:8][C:9]2[CH:10]=[CH:11][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:13][CH:14]=2)=[C:2]([Cl:1])[CH:3]=1)(=[O:36])[CH3:35]

参加物

5

反応物 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 13823230HCID 13823230、化合物

生成物 1

HCID 21286378HCID 21286378、化合物

実験手順

2 g of 2-[3,5-dichloro-4-(4-methylsulfonylphenoxy)phenyl]hexahydro-1,2,4-triazine-3,5-dione were suspended in 10 ml of acetic anhydride. 1 ml of concentrated sulfuric acid was added dropwise, during which there was a slight increase in the temperature of the suspension and the starting material slowly dissolved. The mixture was then stirred at room temperature for 2 to 3 hours, and was subsequently stirred with water. The product was filtered off with suction, washed with water and dried, and recrystallized from a little glacial acetic acid, melting point 267° C.

後処理

  1. temperaturea slight increase in the temperature of the suspension
  2. dissolutionthe starting material slowly dissolved
  3. filtrationThe product was filtered off with suction
  4. washwashed with water
  5. customdried
  6. customrecrystallized from a little glacial acetic acid, melting point 267° C.

出典と根拠

ORDレコード
ord-0b1688980ddd43378d5fa808086afb80
出典データセット
uspto-grants-1988_11
特許番号
US04782056

反応ノート

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