1-Indanone → 1-Indanol

HRID 223119ノート

反応式

HRID 223119 の反応式
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1>C1C=CC=CC=1.CCOCC>[CH:1]1([OH:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 67351-Indanone

生成物 1

HCID 228191-Indanol収率 74.4%

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 3283Diethyl Ether溶媒

反応条件

温度
35 °C

実験手順

20 g Indanone (obtained according to Example VIII) is added to a solution of 1.5 molequivalent NaAlH2 (OC2H4OCH3)2 in a mixture of benzene and ether in the course of which the temperature raises to 35° C. Then the reaction mixture is stirred during one hour, poured out into ice and extracted with ether. The solution in ether is washed with NaCl solution, dried and evaporated. The residue is distilled under diminished pressure yielding 15.1 g indanol. B.p. 115° C./1 mm Hg. The indanol is dissolved in 100 ml cyclohexane and during 30 min. gaseous HCl is introduced followed by N2 to remove the excess of HCl. The reaction mixture is evaporated and the residue is distilled under diminished pressure yielding 12.9 g indanyl chloride. B.p. 95° C./1 mm Hg.

後処理

  1. additionpoured out into ice
  2. extractionextracted with ether
  3. washThe solution in ether is washed with NaCl solution
  4. customdried
  5. customevaporated
  6. distillationThe residue is distilled under diminished pressure

出典と根拠

ORDレコード
ord-228021af54c942849e9dbb71f37de912
出典データセット
uspto-grants-1982_10
特許番号
US04352748

反応ノート

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