Selenium Dioxide → 1-Phenylbenzimidazole-2-carboxaldehyde
反応式
[C:1]1([N:7]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[CH3:16])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Se](=O)=[O:18]>O1CCOCC1>[C:1]1([N:7]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[CH:16]=[O:18])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
To a solution of 5.0 g (0.024 mole) of 1-phenyl-2methylbenzimidazole in 200 ml of dioxane was added 2.66 g (0.024 mole) of selenium dioxide and the reaction heated to reflux for 7 hours. The solids were filtered and the filtrate concentrated to a brown oil. The residue was chromatographed on 200 g of silica gel using 7% ethyl acetate in chloroform as the eluent to give 2.68 g of purified product.
後処理
- temperaturethe reaction heated
- temperatureto reflux for 7 hours
- filtrationThe solids were filtered
- concentrationthe filtrate concentrated to a brown oil
- customThe residue was chromatographed on 200 g of silica gel using 7% ethyl acetate in chloroform as the eluent
出典と根拠
- ORDレコード
- ord-1bd5e0b8009141dc82fbf207db642446
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04782050
反応ノート
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