N-cyclopropylbenzene-1,2-diamine → 1-Cyclopropyl-2-methyl-1H-benzimidazole

HRID 2231243ノート

反応式

HRID 2231243 の反応式
[CH:1]1([NH:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[NH2:11])[CH2:3][CH2:2]1.[CH2:12](C(CC)(CC)C([O-])([O-])[O-])[CH3:13]>C(OCC)(=O)C>[CH:1]1([N:4]2[C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[N:11]=[C:12]2[CH3:13])[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 10582926N-cyclopropylbenzene-1,2-diamineHCID 21875354Triethylorthoaceate

生成物 1

HCID 212862831-Cyclopropyl-2-methyl-1H-benzimidazole収率 94.4%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 1.71 g (0.0115 mole) of N-cyclopropyl-1,2-phenylenediamine and 2.12 ml (0.0115 mole) of triethylorthoacetate in 50 ml of ethyl acetate was heated to reflux for 2 hours. The solvent was removed and the residue partitioned between chloroform and water. The organic phase was separated, dried over sodium sulfate and concentrated to give 1.87 g of a brown oil.

後処理

  1. temperatureto reflux for 2 hours
  2. customThe solvent was removed
  3. customthe residue partitioned between chloroform and water
  4. customThe organic phase was separated
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-675887b0d42e428d85ed6c177ce0e9ed
出典データセット
uspto-grants-1988_11
特許番号
US04782050

反応ノート

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