Selenium Dioxide → 1-cyclopropyl-1H-1,3-benzodiazole-2-carbaldehyde

HRID 2231244ノート

反応式

HRID 2231244 の反応式
[Se](=O)=[O:2].[CH:4]1([N:7]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[CH3:16])[CH2:6][CH2:5]1>O1CCOCC1>[CH:4]1([N:7]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[CH:16]=[O:2])[CH2:6][CH2:5]1

参加物

4

反応物 2

HCID 24007Selenium DioxideHCID 212862831-Cyclopropyl-2-methyl-1H-benzimidazole

生成物 1

HCID 150720581-cyclopropyl-1H-1,3-benzodiazole-2-carbaldehyde収率 57.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Selenium dioxide (1.2 g, 0.011 mole) was added to 60 ml of dioxane containing 1.87 g .(0.011 mole) of 1-cyclopropyl-2-methylbenzimidazole and the reaction heated to reflux for 2.5 hours. The reaction was filtered and the filtrate concentrated to a dark oil, 3.0 g. Chromatographing of the residue on silica gel gave 1.18 g of the desired compound.

後処理

  1. temperatureto reflux for 2.5 hours
  2. filtrationThe reaction was filtered
  3. concentrationthe filtrate concentrated to a dark oil, 3.0 g

出典と根拠

ORDレコード
ord-e0ecb81061674e09bdf6a889217e79f0
出典データセット
uspto-grants-1988_11
特許番号
US04782050

反応ノート

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