Acetic Anhydride → 4'-Acetoxy-5-hydroxy-3,3',7-trimethoxyflavone

HRID 223127

反応式

HRID 223127 の反応式
[OH:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[O:7][C:8]3[C:13]([C:14](=[O:18])[C:15]=2[O:16][CH3:17])=[C:12]([OH:19])[CH:11]=[C:10]([O:20][CH3:21])[CH:9]=3)=[CH:4][C:3]=1[O:24][CH3:25].[C:26]([O-])(=[O:28])[CH3:27].[Na+].C(OC(=O)C)(=O)C>>[C:26]([O:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[O:7][C:8]3[C:13]([C:14](=[O:18])[C:15]=2[O:16][CH3:17])=[C:12]([OH:19])[CH:11]=[C:10]([O:20][CH3:21])[CH:9]=3)=[CH:4][C:3]=1[O:24][CH3:25])(=[O:28])[CH3:27]

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 5281677Pachypodol

生成物 1

HCID 205225554'-Acetoxy-5-hydroxy-3,3',7-trimethoxyflavone収率 90%

反応条件

温度
100 °C

実験手順

A mixture of 250 mg of 4',5-dihydroxy-3,3',7-trimethoxyflavone, 60 mg of sodium acetate and 70 mg of acetic anhydride was heated at 100° C. for 2 hours. The reaction mixture was evaporated under reduced pressure, and the residue was extracted with 30 ml of chloroform. Removal of the solvent from the extract and subsequent recrystallization of the residue from methanol gave 250 mg (90% yield) of 4'-acetoxy-5-hydroxy-3,3',7-trimethoxyflavone as yellow crystals: m.p. 168°-169° C.

後処理

  1. customThe reaction mixture was evaporated under reduced pressure
  2. extractionthe residue was extracted with 30 ml of chloroform
  3. customRemoval of the solvent from the
  4. extractionextract
  5. customsubsequent recrystallization of the residue from methanol

出典と根拠

ORDレコード
ord-1f8793b850b9462e8558abd9f4b2a09e
出典データセット
uspto-grants-1982_10
特許番号
US04352792

関連ノート

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