Hydrochloric Acid → 2-Hydroxybenzo(b)thiophene-3-carboxamide
反応式
[SH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:12]([NH2:14])=[O:13])[C:9](O)=[O:10].Cl.C(O)(=O)CC(N)=O>CN(C)C=O>[OH:10][C:9]1[S:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[C:8]=1[C:12]([NH2:14])=[O:13]参加物
5
反応条件
- 温度
- 100 °C
実験手順
Under a nitrogen atmosphere, a mixture of o-mercaptophenylmalonamic acid (2.1 g, 0.01 m), dimethylformamide (20 ml), and concentrated hydrochloric acid (0.2 ml) are heated in an oil-bath at ca. 100° C. until thin-layer chromatography indicates the absence of starting malonamic acid. The cooled, stirred mixture is diluted with ice-water, aged and filtered to yield 2-hydroxybenzo(b)thiophene-3-carboxamide.
後処理
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-d394fa241c264d91bca83506640d7a32
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04782080
反応ノート
読み込み中…