Hydrochloric Acid → 2-Hydroxybenzo(b)thiophene-3-carboxamide

反応式

C(N[C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[C:6]=1[C:14]#[N:15])(=O)C.C([OH:18])C.Cl.[OH2:20]>>[OH:20][C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[C:6]=1[C:14]([NH2:15])=[O:18]

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 962Water2 回

HCID 21286564N-(3-Cyano-1-benzothiophen-2-yl)acetamide

生成物 1

HCID 142579342-Hydroxybenzo(b)thiophene-3-carboxamide

実験手順

A mixture of 2-acetamido-3-cyanobenzo(b)thiophene (2.2 g, 0.01 m), ethanol (25 ml), water (15 ml) and concentrated hydrochloric acid (25 ml) is heated under reflux for 12 hours. The reaction mixture is diluted with water, aged and filtered to yield 2-hydroxybenzo(b)thiophene-3-carboxamide.