Cyclopropylamine → HCID 67944888、化合物

HRID 2231364ノート

反応式

HRID 2231364 の反応式
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[Cl:5][C:6]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:7]=1[C:8]([C:10](=[CH:13]OC)[C:11]#[N:12])=[O:9]>C(O)C>[Cl:5][C:6]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:7]=1[C:8]([C:10](=[CH:13][NH:4][CH:1]1[CH2:3][CH2:2]1)[C:11]#[N:12])=[O:9]

参加物

4

反応物 2

HCID 69828CyclopropylamineHCID 537392442-(2,4-Dichloro-benzoyl)-3-methoxyacrylonitrile

生成物 1

HCID 67944888HCID 67944888、化合物収率 86.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.5 g of cyclopropylamine are added dropwise to a solution of 11 g of 2-(2,4-dichloro-benzoyl)-3-methoxyacrylonitrile in 40 ml of ethanol, while cooling with ice and stirring. The mixture is stirred at room temperature for 25 minutes and then heated at the boiling point for 15 minutes. The solvent is removed in vacuo and the residue is recrystallized from ethanol/light petrol. 10.5 g of 2-(2,4-dichloro-benzoyl)-3-cyclopropylaminoacrylonitrile of melting point 93°-94° C. are obtained.

後処理

  1. temperaturewhile cooling with ice
  2. stirringThe mixture is stirred at room temperature for 25 minutes
  3. temperatureheated at the boiling point for 15 minutes
  4. customThe solvent is removed in vacuo
  5. customthe residue is recrystallized from ethanol/light petrol

出典と根拠

ORDレコード
ord-d33f65b00dc943f184df450cdc2f4a85
出典データセット
uspto-grants-1988_11
特許番号
US04782156

反応ノート

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