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Triethylamine → 4-Crotonoxy-6-Methyl-2-Trichloromethylpyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | trans-Crotonyl chloride | HCID 643131 | — |
| 反応物 | HCID 178429333 | HCID 178429333 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-Crotonoxy-6-Methyl-2-Trichloromethylpyrimidine | HCID 13051398 | 45% |
反応手順
To a solution of 3.0 g (0.02 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine and 1.3 g (0.02 mole) triethylamine in 75 ml diethyl ether was added 1.4 g (0.02 mole) crotonyl chloride. The reaction mixture was refluxed for 15 hours and filtered, and the filtrate was concentrated in-vacuo to give a viscous oil as residue. Trituration with petroleum ether caused the oil to solidify. Recrystallization from isopropyl alcohol gave 1.8 g (45% yield) of pure product; m.p. 55° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04352806 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-862eea4fe61a46a7a4bd37ce9962335e |
| 出典メモ | uspto-grants-1982_10 |