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Triphenylphosphane dichloride → 7-Chloro-4-methylisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphane dichloride | HCID 13797396 | — |
| 反応物 | 4-Methylisoquinolin-7-ol | HCID 20523221 | — |
| 生成物 | 7-Chloro-4-methylisoquinoline | HCID 20523223 | — |
反応手順
A mixture of 15.9 g. (0.1 mole) of 7-hydroxy-4-methylisoquinoline and 41.7 g. (0.125 mole) of triphenylphosphine dichloride is heated to 230° C. for four hours, cooled, and partitioned between chloroform and concentrated hydrochloric acid. The aqueous phase is neutralized with ammonium hydroxide and extracted with chloroform to yield 7-chloro-4-methylisoquinoline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04352809 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-7610aea6821a4115b13fbaa01e4191c3 |
| 出典メモ | uspto-grants-1982_10 |