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Sulfuric Acid → 7-Chloro-4-methyl-8-nitroisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Potassium Nitrate | HCID 24434 | — |
| 反応物 | 7-Chloro-4-methylisoquinoline | HCID 20523223 | — |
| 生成物 | 7-Chloro-4-methyl-8-nitroisoquinoline | HCID 20523218 | — |
反応手順
A mixture of 17.7 g. (0.1 mole) of 7-chloro-4-methylisoquinoline and 100 ml. of concentrated sulfuric acid is treated with 10 g. (0.1 mole) of potassium nitrate dissolved in 150 ml. of concentrated sulfuric acid. The mixture is stirred for one hour, quenched on ice, made alkaline with ammonium hydroxide and filtered to yield 7-chloro-4-methyl-8-nitroisoquinoline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04352809 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-153a648d1b2f46eea8d8e5555ee8287b |
| 出典メモ | uspto-grants-1982_10 |