反応式
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[C:11]([OH:18])[C:10]=1[CH2:19][CH2:20][CH3:21])[CH3:2].[S:23]([O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32]OS(=O)(=O)C)(=[O:26])(=[O:25])[CH3:24].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.CN(C)C=O>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[C:11]([O:18][CH2:32][CH2:31][O:30][CH2:29][CH2:28][O:27][S:23]([CH3:24])(=[O:26])=[O:25])[C:10]=1[CH2:19][CH2:20][CH3:21])[CH3:2]参加物
反応物 3
生成物 1
試薬・触媒・溶媒 2
実験手順
A mixture of 4 g (0.013 mol) of 4-(4-acetyl-3-hydroxy-2-propylphenoxy)butanoic acid ethyl ester, 17 g (0.065 mol) of diethylene glycol dimesylate and 3.6 g (0.026 mol) of anhydrous potassium carbonate in 80 ml of anhydrous acetone and 40 ml of anhydrous dimethylformamide was stirred at reflux for 20 hours. An additional 1.8 g of potassium carbonate was added and reflux was continued for a total of 44 hours. The reaction mixture was filtered and concentrated in vacuo to an orange oil which was treated with ethyl acetate and sodium chloride solution. The yellow oil obtained on concentration of the ethyl acetate was purified by HPLC, eluting with 15% ethyl acetate/toluene to yield 4.1 g (67% yield) of 4-[4-acetyl-3-[2-[2-[(methylsulfonyl)oxy]ethoxy]-ethoxy]-2-propylphenoxy]butanoic acid ethyl ester as a yellow oil.
後処理
- temperatureat reflux for 20 hours
- temperaturereflux
- customwas continued for a total of 44 hours
- filtrationThe reaction mixture was filtered
- concentrationconcentrated in vacuo to an orange oil which
- additionwas treated with ethyl acetate and sodium chloride solution
- customThe yellow oil obtained on concentration of the ethyl acetate
- customwas purified by HPLC
- washeluting with 15% ethyl acetate/toluene
出典と根拠
- ORDレコード
- ord-0323c499dec241fcbe0cc5d56c29bdf8
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04782176
関連ノート
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