Hydrochloric Acid → 7-Methoxy-1-methylisoquinoline

HRID 223148ノート

反応式

HRID 223148 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[CH:6]([N:8]([CH2:19][CH:20](OC)OC)S(C1C=CC(C)=CC=1)(=O)=O)[CH3:7].O1CCOCC1.Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:25]([CH:20]=[CH:19][N:8]=[C:6]2[CH3:7])=[CH:26][CH:27]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 20523222HCID 20523222、化合物

生成物 1

HCID 159337467-Methoxy-1-methylisoquinoline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 39.3 g. (0.1 mole) of 3-methoxy-α-methyl-N-(2,2-dimethoxyethyl)-N-tosyl-benzylamine, one liter of dioxane and 80 ml. of 6 N hydrochloric acid is refluxed for six hours and allowed to stand for sixteen hours. The mixture is poured into two liters of water and extracted with ether. The aqueous phase is made alkaline with concentrated ammonium hydroxide and extracted with chloroform. The chloroform extract is washed, dried and evaporated to yield 7-methoxy-1-methylisoquinoline.

後処理

  1. additionA mixture of 39.3 g
  2. waitto stand for sixteen hours
  3. extractionextracted with ether
  4. extractionextracted with chloroform
  5. extractionThe chloroform extract
  6. washis washed
  7. customdried
  8. customevaporated

出典と根拠

ORDレコード
ord-bae13efb8328448aab3dd8acd161d615
出典データセット
uspto-grants-1982_10
特許番号
US04352809

反応ノート

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