3-Amino-1-propanol → 2-t-Butyl-4-n-propyl-5-(3-hydroxypropylamino)-3(2H) pyridazinone

HRID 2231679ノート

反応式

HRID 2231679 の反応式
[C:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12][CH2:13][CH3:14])=[C:8](Cl)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[OH:16][CH2:17][CH2:18][CH2:19][NH2:20].C(=O)([O-])[O-].[K+].[K+]>O>[C:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12][CH2:13][CH3:14])=[C:8]([NH:20][CH2:19][CH2:18][CH2:17][OH:16])[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 90863-Amino-1-propanolHCID 11430Potassium CarbonateHCID 199031582-t-butyl-4-n-propyl-5-chloro-3(2H)pyridazinone

生成物 1

HCID 139878402-t-Butyl-4-n-propyl-5-(3-hydroxypropylamino)-3(2H) pyridazinone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture comprising 14.0 g of 2-t-butyl-4-n-propyl-5-chloro-3(2H)pyridazinone, 44 g of 3-hydroxypropylamine and 14.8 g of anhydrous potassium carbonate, was stirred at a temperature of from 145° to 155° C. for 12.5 hours. The reaction solution was returned to room temperature, and about 200 ml of cold water was added. The mixture was stirred. The precipitated white crystals were collected by filtration, and dried to obtain 12.1 g of the above identified compound having a melting point of from 167° to 169° C.

後処理

  1. customwas returned to room temperature
  2. stirringThe mixture was stirred
  3. filtrationThe precipitated white crystals were collected by filtration
  4. customdried
  5. customto obtain 12.1 g of the
  6. customof from 167° to 169° C.

出典と根拠

ORDレコード
ord-512a0777c6c84489a38e46f210ff83d3
出典データセット
uspto-grants-1988_11
特許番号
US04783462

反応ノート

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