化工社化工社 化学情報印刷レポート · 研究参考用
Lithium borohydride → 2-Fluoro-4-(hydroxymethyl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium borohydride | HCID 4148881 | — |
| 反応物 | Ethyl 4-cyano-3-fluorobenzoate | HCID 21284546 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Fluoro-4-(hydroxymethyl)benzonitrile | HCID 11829631 | — |
反応手順
40 g of ethyl 4-cyano-3-fluorobenzoate in 40 ml of THF are added dropwise to a solution of 8 g of LiBH4 in 120 ml of THF. In the course of this, the reaction mixture comes to the boil. After one hour it is acidified with 2NHCl and worked up in a customary manner. 3-Fluoro-4-cyanobenzyl alcohol, m.p. 70°-72° C., is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04784471 |
| 出典データセット | uspto-grants-1988_11 |
| ORD ID | ord-c8861f08df674d4b950967272d1f04b9 |
| 出典メモ | uspto-grants-1988_11 |