Ethyl bromopyruvate → HCID 21284871、化合物
反応式
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([NH2:12])=[S:11].[Br:13][CH2:14][C:15](=O)[C:16]([O:18][CH2:19][CH3:20])=[O:17]>C(O)C>[BrH:13].[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[S:11][CH:14]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:12]=1参加物
4
実験手順
0.065 mole of 1-(2-hydroxy-4-methylphenyl)-2-thiourea and 0.077 mole of ethyl bromopyruvate in 100 ml of 95° strength ethanol are brought to reflux for 3 hours. After evaporation of the solvent, crystallization of the residual oil is induced in diethyl ether. The product is then recrystallized in an ethanol/ether mixture. (M.p. 158°-60° C.) yield: 65%.
後処理
- temperatureto reflux for 3 hours
- customAfter evaporation of the solvent, crystallization of the residual oil
- customThe product is then recrystallized in an ethanol/ether mixture
出典と根拠
- ORDレコード
- ord-0e97926e0aae459d9e1a97601b2631f9
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04785008
反応ノート
読み込み中…