Aluminum(III) Chloride → HCID 178454735、化合物

HRID 2231933ノート

反応式

HRID 2231933 の反応式
[OH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:11][CH:12]([CH2:16][C:17]([O:19]C)=[O:18])[C:13](Cl)=[O:14].[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[C:17]([CH2:16][CH:12]([CH3:11])[C:13]([C:8]1[CH:9]=[CH:10][C:4]2[N:3]=[C:2]([OH:1])[NH:6][C:5]=2[CH:7]=1)=[O:14])([OH:19])=[O:18]

参加物

5

反応物 3

HCID 6451240Aluminum(III) ChlorideHCID 14403282Methyl 4-chloro-3-methyl-4-oxobutanoateHCID 178517141HCID 178517141、化合物

生成物 1

HCID 178454735HCID 178454735、化合物

試薬・触媒・溶媒 1

HCID 6348Carbon Disulfide溶媒

実験手順

Carbon disulfide (90 ml), 2-hydroxybenzimidazole (4.1 g) and 2-methyl-3-carbomethoxy propionyl chloride (5 g) are added to aluminum chloride (20.3 g) under nitrogen. The resulting mixture is refluxed for about 45 hours, quenched with ice cold 6N HCl and the acidic mixture filtered. The filtered solid is washed with water and dried in vacuo, affording the desired product as a solid, M.P. 223° C. (dec).

後処理

  1. temperatureThe resulting mixture is refluxed for about 45 hours
  2. customquenched with ice cold 6N HCl
  3. filtrationthe acidic mixture filtered
  4. washThe filtered solid is washed with water
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-e91786e259844d7dbe0ec06c77c21268
出典データセット
uspto-grants-1988_11
特許番号
US04785101

反応ノート

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