N-Hydroxyphthalimide → HCID 21285061、化合物

HRID 2231985

反応式

HRID 2231985 の反応式
O[N:2]1[C:6](=[O:7])[C:5]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:4]2[C:3]1=[O:12].[C:13](=[O:16])([O-])[O-].[K+].[K+].ClC[C:21]1[N:22]=[C:23]([NH:26][C:27]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[S:24][CH:25]=1>CN(C)C=O.C1CC2OCCOCCOC3C(OCCOCCOC2CC1)CCCC3>[C:27]([NH:26][C:23]1[S:24][CH:25]=[C:21]([CH2:13][O:16][C:8]2[CH:9]=[CH:10][CH:11]=[C:4]3[C:3]([NH:2][C:6](=[O:7])[C:5]=23)=[O:12])[N:22]=1)([C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)([C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

参加物

6

反応物 3

HCID 10665N-HydroxyphthalimideHCID 11430Potassium CarbonateHCID 137451724-Chloromethyl-2-tritylaminothiazole

生成物 1

HCID 21285061HCID 21285061、化合物収率 96.1%

試薬・触媒・溶媒 2

HCID 85955Dicyclohexano-18-crown-6触媒HCID 6228Dimethylformamide溶媒

実験手順

8.15 g of N-hydroxyphthalimide was dissolved in 300 ml of N,N-dimethylformamide, 6.91 g of potassium carbonate and 200 mg of dicyclohexyl-18-crown-6 were added, and stirred at room temperature for 2 hours. Thereafter, 9.82 g of 4-chloromethyl-2-tritylaminothiazol was added thereto, and stirred and reacted at room temperature for 8 hours. The reaction mixture was concentrated under reduced pressure, and, after adding 500 ml of ethyl acetate, washed with 300 ml of water 4 times. The ethyl acetate layer was dried on anhydrous magnesium sulfate, and concentrated to dryness to obtain 12.5 g of (2-tritylaminothiazol-4-yl)methoxyphthalimide.

後処理

  1. stirringstirred
  2. customreacted at room temperature for 8 hours
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. additionafter adding 500 ml of ethyl acetate
  5. washwashed with 300 ml of water 4 times
  6. dry with materialThe ethyl acetate layer was dried on anhydrous magnesium sulfate
  7. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-45a65fe7a25b40b08ba6844b4201d3f1
出典データセット
uspto-grants-1988_11
特許番号
US04785090

関連ノート

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