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N-[2-(N,N-dimethylsulfamoyl)-phenylsulfonyl]-N'-(4-chloromethyl-6-methoxypyrimidin-2-yl)-urea → N-(2-Dimethylsulfamoylphenyl-sulfonyl)-N'-(4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidin-2-yl)-urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[2-(N,N-dimethylsulfamoyl)-phenylsulfonyl]-N'-(4-chloromethyl-6-methoxypyrimidin-2-yl)-urea | HCID 13884816 | — |
| 反応物 | Sodium dimethyldithiocarbamate dihydrate | HCID 23693613 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(2-Dimethylsulfamoylphenyl-sulfonyl)-N'-(4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidin-2-yl)-urea | HCID 20070845 | — |
反応手順
A mixture of 9.3 g of N-(2-dimethylsulfamoylphenylsulfonyl)-N'-(4-chloromethyl-6-methoxy-pyrimidin-2-yl)-urea and 3.7 g of dimethyldithiocarbamic acid sodium salt dihydrate is stirred in 100 ml of acetonitrile at 20°-25° C. for 3 hours. In further processing, the reaction mixture is diluted with 1 liter of water, and the precipitated product is separated. The yield is 10.0 g (91% of theory) of N-(2-dimethylsulfamoylphenyl-sulfonyl)-N'-(4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidin-2-yl)-urea m.p. 181°-183° C. (decomp.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04786315 |
| 出典データセット | uspto-grants-1988_11 |
| ORD ID | ord-e4c39a332030435c8f83e9871f62ca4a |
| 出典メモ | uspto-grants-1988_11 |