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4-(Chloromethyl)-6-methoxypyrimidin-2-amine → 2-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Chloromethyl)-6-methoxypyrimidin-2-amine | HCID 13884815 | — |
| 反応物 | Sodium dimethyldithiocarbamate dihydrate | HCID 23693613 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine | HCID 20070829 | — |
反応手順
18.5 g of dimethyldithiocarbamic acid sodium salt dihydrate and 17.4 g of 2-amino-4-chloromethyl-6-methoxypyrimidine are refluxed in 100 ml of ethanol for 30 minutes. After the mixture has been cooled, it is diluted with about 1 liter of water, and the product which has precipitated is separated and dried. The yield is 23.0 g (89% of theory) of 2-amino-4-methoxy-6-dimethylthiocarbamoylthiomethyl-pyrimidine, m.p. 118°-120° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04786315 |
| 出典データセット | uspto-grants-1988_11 |
| ORD ID | ord-d0100ed16aac45a8a85d8590fe2dccae |
| 出典メモ | uspto-grants-1988_11 |