2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → 5-Amino-4-ethoxycarbonyl-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole

HRID 2232175ノート

反応式

HRID 2232175 の反応式
[F:1][C:2]1[C:7]([F:8])=[C:6]([C:9]([F:12])([F:11])[F:10])[C:5]([F:13])=[C:4]([F:14])[C:3]=1[NH:15][NH2:16].C(O[CH:20]=[C:21]([C:27]#[N:28])[C:22]([O:24][CH2:25][CH3:26])=[O:23])C>C(O)C>[NH2:28][C:27]1[N:15]([C:3]2[C:2]([F:1])=[C:7]([F:8])[C:6]([C:9]([F:12])([F:11])[F:10])=[C:5]([F:13])[C:4]=2[F:14])[N:16]=[CH:20][C:21]=1[C:22]([O:24][CH2:25][CH3:26])=[O:23]

参加物

4

反応物 2

HCID 789432-Propenoic acid, 2-cyano-3-ethoxy-, ethyl esterHCID 298179(alpha,alpha,alpha,2,3,5,6-Heptafluoro-p-tolyl)hydrazine

生成物 1

HCID 139337085-Amino-4-ethoxycarbonyl-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole収率 87.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

40 g (0.161 mol) of 2,3,5,6-tetrafluoro-4-trifluoromethylphenylhydrazine and 27.8 g (0.161 mol) of ethyl ethoxymethylenecyanoacetate are dissolved in 70 ml of ethanol and the solution is warmed under reflux for 10 hours. The solvent is distilled off in vacuo, the residue is suspended in 100 ml of diethyl ether, the suspension is filtered and the solid is dried. 52.2 g (87.4% of theory) of 5-amino-4-ethoxycarbonyl-1-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenyl)-pyrazole of melting point 175° C.-176° C. are obtained.

後処理

  1. temperaturethe solution is warmed
  2. temperatureunder reflux for 10 hours
  3. distillationThe solvent is distilled off in vacuo
  4. filtrationthe suspension is filtered
  5. customthe solid is dried

出典と根拠

ORDレコード
ord-6a2863a51dcf42b8814ae7265b38d15a
出典データセット
uspto-grants-1988_11
特許番号
US04787930

反応ノート

読み込み中…