1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one → N-(4-Methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

HRID 2232291ノート

反応式

HRID 2232291 の反応式
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)=O.C(=O)(O)O.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]([NH2:29])=[NH:28])=[CH:22][CH:21]=1>C(O)(C)C>[CH3:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([NH:26][C:27]2[N:29]=[C:5]([C:7]3[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=3)[CH:4]=[CH:3][N:28]=2)=[CH:24][CH:25]=1

参加物

4

反応物 2

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneHCID 178492308HCID 178492308、化合物

生成物 1

HCID 14346975N-(4-Methoxyphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of 14.4 g of 3-dimethylamino-1-(3-pyridinyl)-2-propen-1-one and 16.1 g of 4-methoxyphenyl guanidine carbonate in 200 ml of isopropanol was heated at reflux for 20 hours. The reaction mixture was cooled, the crude product was collected by filtration and washed with water. The material was recrystallized from isopropanol to give the desired product as light yellow crystals, mp 121°-122° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 20 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe crude product was collected by filtration
  5. washwashed with water
  6. customThe material was recrystallized from isopropanol

出典と根拠

ORDレコード
ord-beda8f0435cb45c199fadb076cd67f63
出典データセット
uspto-grants-1988_11
特許番号
US04788195

反応ノート

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