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3-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one → N-(4-Methoxyphenyl)-4-(2-thienyl)-2-pyrimidinamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one | HCID 602399 | — |
| 反応物 | HCID 178492308 | HCID 178492308 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | N-(4-Methoxyphenyl)-4-(2-thienyl)-2-pyrimidinamine | HCID 14346981 | 61.2% |
反応手順
A mixture of 10.9 g of 3-dimethylamino-1-(2-thienyl)-2-propen-1-one (U.S. Pat. No. 4,374,988) and 11.8 g of 4-methoxyphenylguanidine carbonate in 150 ml of isopropanol was heated at reflux for 48 hours. The solution was cooled, then filtered, giving 9.0 g of the desired product as yellow crystals, mp 158°-160° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04788195 |
| 出典データセット | uspto-grants-1988_11 |
| ORD ID | ord-d7e4482e527c4d02a3a3f2c2690b940e |
| 出典メモ | uspto-grants-1988_11 |