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Boron trifluoride → 4,4-Dimethyl-6,7-dimethoxy-1-bromomethylisochroman
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron trifluoride | HCID 6356 | — |
| 反応物 | Acetaldehyde, bromo- | HCID 105131 | — |
| 反応物 | 2-(3,4-Dimethoxyphenyl)-2-methylpropan-1-ol | HCID 13015778 | — |
| 溶媒 | Nitromethane | HCID 6375 | — |
| 生成物 | 4,4-Dimethyl-6,7-dimethoxy-1-bromomethylisochroman | HCID 20523070 | — |
反応手順
A 2,2-Dimethyl-2-(3,4-dimethoxyphenyl)ethanol (0.95 g, 0.0045 m) is stirred with 1.07 g (0.0054 m) of the ethyl acetal of bromoacetaldehyde and 0.19 g (0.0014 m) of BF3 .etherate in 25 ml of nitromethane for 15 hours. The mixture is partitioned between methylene chloride and aqueous sodium carbonate. The organic phase is dried over sodium sulfate and concentrated to yield 1.52 g of 4,4-dimethyl-6,7-dimethoxy-1-bromomethylisochroman. The nmr is consistent with the assigned structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04352805 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-3e4b66a471a743eabefd0a20575541a1 |
| 出典メモ | uspto-grants-1982_10 |