Imidazo[1,2-a]pyridine-6-carboxamide → imidazo[1,2-a]pyridine-6-carbonitrile
反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:8]([CH:10]=[CH:11][N:12]=2)[CH:9]=1)(=O)[NH2:2]>P(Cl)(Cl)(Cl)=O>[C:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:8]([CH:10]=[CH:11][N:12]=2)[CH:9]=1)#[N:2]参加物
3
実験手順
A mixture of 2.6 g of 6-carbamoylimidazo[1,2-a]pyridine and 30 ml of phosphorus oxychloride is heated under reflux for 16 hours. The excess phosphorus oxychloride is removed under reduced pressure and the residue is poured onto ice. The mixture is neutralized with sodium carbonate and extracted with ethyl acetate. The organic layer is washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent is then evaporated off under reduced pressure to give 2.0 g of the above-identified compound as colorless crystals.
後処理
- temperatureis heated
- temperatureunder reflux for 16 hours
- customThe excess phosphorus oxychloride is removed under reduced pressure
- additionthe residue is poured onto ice
- extractionextracted with ethyl acetate
- washThe organic layer is washed with saturated aqueous sodium chloride solution
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent is then evaporated off under reduced pressure
出典と根拠
- ORDレコード
- ord-b739f3c701f242c69f0000c197c47428
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04788185
反応ノート
読み込み中…