Sulfuric Acid → 2,3-Dichloro-4,5-difluorobenzamide

HRID 2232643ノート

反応式

HRID 2232643 の反応式
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:14]>>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([F:11])[C:7]([F:12])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:14]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 140963672,3-Dichloro-4,5-difluorobenzonitrile

生成物 1

HCID 140963682,3-Dichloro-4,5-difluorobenzamide

実験手順

A solution of 2,3-dichloro-4,5-difluorobenzonitrile (1.0 g) in concentrated sulfuric acid (2.5 ml) was stirred at 90° to 100° C. for 30 minutes and then cooled. The residue was poured into ice water and the resulting precipitate was collected by filtration and recrystallized from benzene to give the title compound (0.51 g) as colorless needles, mp 153°-155° C.

後処理

  1. temperaturecooled
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from benzene

出典と根拠

ORDレコード
ord-83c42384b2eb40df9ff8dc5fc64473f5
出典データセット
uspto-grants-1988_11
特許番号
US04788320

反応ノート

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