Methylamine → 1,2-Benzenediol, 1-(N-methylcarbamate)
反応式
[C:1]([O:4][C:5]1[C:6](=[CH:8][CH:9]=[CH:10][CH:11]=1)[OH:7])(=O)[OH:2].[CH3:12][NH2:13]>>[CH3:12][NH:13][C:1]([O:4][C:5]1[C:6](=[CH:8][CH:9]=[CH:10][CH:11]=1)[OH:7])=[O:2]参加物
3
実験手順
In fact, the reaction of pyrocatechol carbonate with methylamine in the presence of not less than 1 mol equivalent of the abovementioned secondary amines gives pyrocatechol monomethylcarbamate in a yield of 98-99%. The subsequent reaction of the reaction mixture with 1,2-dichloroethyl methyl ether in turn takes place with a yield of above 90%. Compared with the reaction with tertiary amines, the conversion takes place substantially more rapidly (on the bas-is of experience, from eight to ten times faster) and with better selectivity, and consequently a purer and more stable end product is obtained.
出典と根拠
- ORDレコード
- ord-f565a8cc4a7b4e75acdcdf4d7a683b3f
- 出典データセット
- uspto-grants-1988_11
- 特許番号
- US04788324
反応ノート
読み込み中…