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4-Phenylpiperidine → 7-methoxy-3,4-dimethyl-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Phenylpiperidine | HCID 69873 | — |
| 反応物 | Fumarate | HCID 5460307 | — |
| 反応物 | 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one | HCID 19927678 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 7-methoxy-3,4-dimethyl-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927681 | 64% |
反応手順
Method A (9 h at 60° C.); starting materials: 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-3,4-dimethyl-2H-1-benzopyran-2-one (example 75) and 4-phenylpiperidine; yield 64%; fusion point 152°-153° C. (from ethanol and isopropanol). Fumarate (×0.5 C4H4O4): method E; yield 92%; fusion point 209°-210° C. (from ethanol and methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05428038 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-27d533dd5f99403a86ddd4adb5d31e9f |
| 出典メモ | uspto-grants-1995_06 |