Potassium Hydroxide → HCID 14347235、化合物

HRID 2232743ノート

反応式

HRID 2232743 の反応式
C([O:3][C:4](=[O:21])/[CH:5]=[CH:6]/[CH:7]=[C:8]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)C.[OH-].[K+]>CO>[C:9]1([C:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7]/[CH:6]=[CH:5]/[C:4]([OH:21])=[O:3])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 14196832Ethyl (2E)-5,5-diphenyl-2,4-pentadienoate

生成物 1

HCID 14347235HCID 14347235、化合物収率 86.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of (E)-5,5-diphenyl-2,4-pentadieneoic acid ethyl ester (15 g) in methanol (80 mL) was treated with a 4N potassium hydroxide solution (20 mL) and the mixture was stirred at reflux for 45 minutes. Most of the methanol was removed under reduced pressure, then the residual solution was poured over ice containing 3N hydrochloric acid (30 mL). The resulting solid was collected by filtration, washed with water and dried. Crystallization of the crude material from 2-propanol furnished 11.7 g of (E)-5,5-diphenyl-2,4-pentadienoic acid mp 193°-194° C. Recrystallization from the same solvent did not affect the melting point.

後処理

  1. temperatureat reflux for 45 minutes
  2. customMost of the methanol was removed under reduced pressure
  3. additionthe residual solution was poured over ice containing 3N hydrochloric acid (30 mL)
  4. filtrationThe resulting solid was collected by filtration
  5. washwashed with water
  6. customdried
  7. customCrystallization of the crude material from 2-propanol

出典と根拠

ORDレコード
ord-5e86e1f8236e40fb9108c8700b98d750
出典データセット
uspto-grants-1988_11
特許番号
US04788206

反応ノート

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