5-methyl-6-nitro-1H-indazole → 5-methyl-1H-indazol-6-amine
反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-])=O)[NH:7][N:6]=[CH:5]2>C(O)C.O.N>[NH2:11][C:10]1[CH:9]=[C:8]2[C:4]([CH:5]=[N:6][NH:7]2)=[CH:3][C:2]=1[CH3:1]参加物
5
実験手順
8 g (45.2 mmol) of 5-methyl-6-nitro-indazole (formula 51), obtained according to E. Noelting, Ber. Dtsch. Chem. Ges. 37 (1904) 2556, are dissolved in 640 ml of 50% aqueous ethanol. A mixture of 80 g of ferrous sulphate in 400 ml of water and 80 ml of aqueous ammonia were added. The reaction mixture was refluxed for 20 hours and filtered while still hot. Removal of the ethanol and purification of the precipitated product with charcoal yielded 4.80 g (72%) of the target compound, m.p. 241°-242° C.
後処理
- additionwere added
- temperatureThe reaction mixture was refluxed for 20 hours
- filtrationfiltered while still hot
- customRemoval of the ethanol and purification of the precipitated product with charcoal
出典と根拠
- ORDレコード
- ord-fb3ea4d420e54dd1a56ed33b0f20ad0c
- 出典データセット
- uspto-grants-1982_10
- 特許番号
- US04352931
反応ノート
読み込み中…