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1-(3-Chloropropyl)-4-phenylpiperidine → 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-(trifluoromethyl)-2H-1-benzopyran-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Chloropropyl)-4-phenylpiperidine | HCID 203689 | — |
| 反応物 | Fumarate | HCID 5460307 | — |
| 反応物 | 6-hydroxy-7-methoxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one | HCID 19927739 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | tert-Butyl methyl ether | HCID 15413 | — |
| 生成物 | 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-4-(trifluoromethyl)-2H-1-benzopyran-2-one | HCID 19927695 | 45% |
反応手順
Method D (3 h at 85° C.); starting materials: 6-hydroxy-7-methoxy-4-(trifluoromethyl)-2H-1-benzopyran-2-one (example 104) and 1-(3-chloropropyl)-4-phenylpiperidine; yield 45%; fusion point 125°-126° C. (from TBME and methanol). Fumarate: method E; yield 59%; fusion point 176°-179° C. (from ethanol and TBME).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05428038 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-ee803333f37a47e09dae10cb3370c666 |
| 出典メモ | uspto-grants-1995_06 |