Hydrochloric Acid → HCID 178425692、化合物

HRID 223295

反応式

HRID 223295 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][N:3]=1.[NH:10]1[CH:17]=[CH:16][C:14](=[O:15])[NH:13][C:11]1=[S:12].Cl.C(=O)(O)[O-].[Na+]>CO>[OH:15][C:14]1[C:16]([CH:8]([C:5]2[CH:4]=[N:3][C:2]([CH3:1])=[CH:7][CH:6]=2)[OH:9])=[CH:17][N:10]=[C:11]([SH:12])[N:13]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 1269845ThiouracilHCID 101925666-Methyl-3-pyridinecarboxaldehyde

生成物 1

HCID 178425692HCID 178425692、化合物収率 45.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 5 g (0.04 mol) of 2-methyl-5-formylpyridine, 5.29 g (0.04 mol) of 2-thiouracil and 50 ml of concentrated hydrochloric acid was heated overnight. The solution was neutralized with sodium bicarbonate. The organic material in the resulting precipitate was taken up in methanol which was then evaporated to give 4.53 g (45%) of 4-hydroxy-2-mercapto-5-[(6-methyl-3-pyridinyl)hydroxymethyl]pyrimidine [MS(m/e)250]. This compound (2 g) is treated with zinc-acetic acid as in Example 9 to give the same end product.

後処理

  1. temperaturewas heated overnight
  2. customwas then evaporated

出典と根拠

ORDレコード
ord-601f016ed5d34e738800626982a3c2c2
出典データセット
uspto-grants-1982_10
特許番号
US04352933

関連ノート

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