Sodium Methoxide → 7-Fluoro-2-methoxy-8-methylquinoxaline
反応式
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[C:5]([CH3:13])[C:6]([F:12])=[CH:7][CH:8]=2)[N:3]=1.[CH3:14][O-:15].[Na+]>CO>[F:12][C:6]1[C:5]([CH3:13])=[C:4]2[C:9]([N:10]=[CH:11][C:2]([O:15][CH3:14])=[N:3]2)=[CH:8][CH:7]=1参加物
4
実験手順
2-Chloro-7-fluoro-8-methylquinoxaline (4.1 g, 20.9 mmol) was suspended in dry methanol and a 25% solution of sodium methoxide in methanol (4.73 ml, 21.9 mmol) was added by syringe. The mixture was heated under reflux for 2 h, then evaporated. The residue was dissolved in dichloromethane and water and the phases were separated. The aqueous phase was extracted twice with dichloromethane, and combined organic fractions were dried and evaporated to give product (3.84 g, 96%).
後処理
- temperatureThe mixture was heated
- temperatureunder reflux for 2 h
- customevaporated
- dissolutionThe residue was dissolved in dichloromethane
- customwater and the phases were separated
- extractionThe aqueous phase was extracted twice with dichloromethane
- customwere dried
- customevaporated
出典と根拠
- ORDレコード
- ord-a142b70347a1436ba085ad7f7903088e
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709483B2
反応ノート
読み込み中…