1-Bromo-3-chloropropane → 4-(3-Chloropropyl)morpholine
反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH:8]=[CH:9][CH2:10][Cl:11].BrCCCCl>C1(C)C=CC=CC=1>[Cl:11][CH2:10][CH2:9][CH2:8][N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1参加物
5
実験手順
A mixture of morpholine (261 ml, 3.00 mol) and 1-bromo-3-chloropropene (148 ml, 1.50 mol) in toluene (900 ml) was stirred for 18 hours at ambient temperature. Additional 1-bromo-3-chloropropane (25 ml, 0.25 mol) was added, the reaction was stirred for a further 1 hour and then filtered to remove the precipitated solid before the filtrate was concentrated in vacuo. Distillation of the crude oil yielded N-(3-chloropropyl)-morpholine (119.3 g, 49% yield) as the fraction boiling at 70-80° C./2.6 mmHg:
後処理
- stirringthe reaction was stirred for a further 1 hour
- filtrationfiltered
- customto remove the precipitated solid before the filtrate
- concentrationwas concentrated in vacuo
- distillationDistillation of the crude oil
出典と根拠
- ORDレコード
- ord-eb5c374e58a245c4a4df052e979a4c7d
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709479B1
反応ノート
読み込み中…