Ammonium Acetate → Methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

HRID 2233396ノート

反応式

HRID 2233396 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=O)[O:7][CH:6]=[C:5]2[C:13]([O:15][CH3:16])=[O:14].C([O-])(=O)C.[NH4+:21]>C(O)(=O)C.O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:7])[NH:21][CH:6]=[C:5]2[C:13]([O:15][CH3:16])=[O:14]

参加物

5

反応物 2

HCID 517165Ammonium AcetateHCID 53429436Methyl 6-fluoro-1-oxo-1H-2-benzopyran-4-carboxylate

生成物 1

HCID 53429435Methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A mixture of methyl 6-fluoro-1-oxo-1H-isochromene-4-carboxylate (1.53 g) and ammonium acetate (2.5 g) in 4 ml of glacial acetic acid was heated at 80° C. for 16 h. The reaction was cooled to 40° C., diluted with 8 ml of water and the solid collected by filtration (1.38 g).

後処理

  1. temperatureThe reaction was cooled to 40° C.
  2. filtrationthe solid collected by filtration (1.38 g)

出典と根拠

ORDレコード
ord-0696056d71c94423a6f96b4a14231836
出典データセット
uspto-grants-2010_05
特許番号
US07709500B2

反応ノート

読み込み中…