Cesium carbonate → HCID 59296163、化合物

反応式

F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[CH2:14]([C:18]1[N:19]=[C:20]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)[S:21][C:22]=1[CH2:23][OH:24])[CH2:15][CH2:16][CH3:17].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[CH2:14]([C:18]1[N:19]=[C:20]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:33])([F:34])[F:32])=[CH:27][CH:26]=2)[S:21][C:22]=1[CH2:23][O:24][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1)[CH2:15][CH2:16][CH3:17]

参加物

実験手順

To a solution of 100 mg of 4-fluoro-2-trifluoromethyl benzonitrile in 5 ml of anhydrous dimethylformamide was added 200 mg of [4-butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol and 0.49 g of cesium carbonate. The resulting mixture was stirred at room temperature overnight, poured onto water and extracted with heptane 1/ethyl acetate 3. The organic extracts were dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel (heptane 4/ethyl acetate 1) to give 180 mg of 4-[4-butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-2-trifluoromethyl-benzonitrile.