Hydrochloric Acid → 1-(3-Nitropyridin-2-yl)piperidin-4-amine hydrochloride
反応式
[ClH:1].[N+:2]([C:5]1[C:6]([N:11]2[CH2:16][CH2:15][CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][CH2:12]2)=[N:7][CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3]>O1CCOCC1>[ClH:1].[N+:2]([C:5]1[C:6]([N:11]2[CH2:16][CH2:15][CH:14]([NH2:17])[CH2:13][CH2:12]2)=[N:7][CH:8]=[CH:9][CH:10]=1)([O-:4])=[O:3]参加物
4
実験手順
A solution of 4 N hydrochloric acid in dioxane (10 ml) was added to tert-butyl [1-(3-nitropyridin-2-yl)piperidin-4-yl]carbamate (Intermediate 38; 1.3 g, 4.2 mmol). The mixture was stirred at room temperature for 1 h under nitrogen gas. The solvent was removed in vacuo to give the title compound as a yellow powder (500 mg).
後処理
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-1094a111bd8d4978940bdef8e01aff93
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709503B2
反応ノート
読み込み中…