Hydrochloric Acid → 6-(4-Aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-amine hydrochloride

HRID 2233841ノート

反応式

HRID 2233841 の反応式
[ClH:1].[NH2:2][C:3]1[N:8]=[C:7]([S:9][CH3:10])[N:6]=[C:5]([N:11]2[CH2:16][CH2:15][CH:14]([NH:17]C(=O)OC(C)(C)C)[CH2:13][CH2:12]2)[CH:4]=1>O1CCOCC1>[ClH:1].[NH2:17][CH:14]1[CH2:15][CH2:16][N:11]([C:5]2[N:6]=[C:7]([S:9][CH3:10])[N:8]=[C:3]([NH2:2])[CH:4]=2)[CH2:12][CH2:13]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68580046tert-Butyl 1-[6-amino-2-(methylthio)pyrimidin-4-yl]piperidin-4-ylcarbamate2 回

生成物 1

HCID 685798436-(4-Aminopiperidin-1-yl)-2-(methylthio)pyrimidin-4-amine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

4 N Hydrogen chloride in dioxane (3 ml) was added to tert-butyl 1-[6-amino-2-(methylthio)pyrimidin-4-yl]piperidin-4-ylcarbamate (Intermediate 45, 0.29 mg 0.86 mmol). The mixture was stirred at room temperature for 90 minutes. The solvent was removed in vacuo to afford the title compound (238 mg).

後処理

  1. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-2c5bb347f265437e81bf009cf111d789
出典データセット
uspto-grants-2010_05
特許番号
US07709503B2

反応ノート

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