Hydrazine → tert-Butyl 1-[6-chloro-4-(hydrazinocarbonyl)pyridin-2-yl]piperidin-4-ylcarbamate

HRID 2233844ノート

反応式

HRID 2233844 の反応式
[NH2:1][NH2:2].[C:3]([O:7][C:8]([NH:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:18]=[C:19]([CH:24]=[C:25]([Cl:27])[N:26]=2)[C:20](OC)=[O:21])[CH2:13][CH2:12]1)=[O:9])([CH3:6])([CH3:5])[CH3:4]>C(O)(C)C>[Cl:27][C:25]1[N:26]=[C:17]([N:14]2[CH2:13][CH2:12][CH:11]([NH:10][C:8](=[O:9])[O:7][C:3]([CH3:4])([CH3:5])[CH3:6])[CH2:16][CH2:15]2)[CH:18]=[C:19]([C:20]([NH:1][NH2:2])=[O:21])[CH:24]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 86608242Methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6-chloroisonicotinate2 回

生成物 1

HCID 86608244tert-Butyl 1-[6-chloro-4-(hydrazinocarbonyl)pyridin-2-yl]piperidin-4-ylcarbamate収率 87.9%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Hydrazine (0.55 ml 17.0 mmol) was added to a solution of methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6-chloroisonicotinate (Intermediate 23, 0.15 g, 0.40 mmol) in isopropanol (3 ml). The mixture was stirred at room temperature overnight then the isopropanol was removed in vacuo to give the title product (130 mg).

後処理

  1. customthe isopropanol was removed in vacuo

出典と根拠

ORDレコード
ord-d153e6a1920144729eb5b48f5d035018
出典データセット
uspto-grants-2010_05
特許番号
US07709503B2

反応ノート

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