Hydrochloric Acid → 5-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]-1,3,4-oxadiazol-2(5H)-one hydrochloride

HRID 2233846ノート

反応式

HRID 2233846 の反応式
Cl.[Cl:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11][CH2:10]2)[CH:6]=[C:5]([CH:23]2[N:27]=[N:26][C:25](=[O:28])[O:24]2)[CH:4]=1>O1CCOCC1>[ClH:2].[NH2:15][CH:12]1[CH2:13][CH2:14][N:9]([C:7]2[CH:6]=[C:5]([CH:23]3[O:24][C:25](=[O:28])[N:26]=[N:27]3)[CH:4]=[C:3]([Cl:2])[N:8]=2)[CH2:10][CH2:11]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86608245tert-Butyl 1-[6-chloro-4-(5-oxo-2,5-dihydro-1,3,4-oxadiazol-2-yl)pyridin-2-yl]piperidin-4-ylcarbamate2 回

生成物 1

HCID 866082465-[2-(4-Aminopiperidin-1-yl)-6-chloropyridin-4-yl]-1,3,4-oxadiazol-2(5H)-one hydrochloride収率 188.1%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

4 N Hydrochloric acid in dioxane (3 ml) was added to tert-butyl 1-[6-chloro-4-(5-oxo-2,5-dihydro-1,3,4-oxadiazol-2-yl)pyridin-2-yl]piperidin-4-ylcarbamate (Intermediate 50, 0.12 mg, 0.32 mmol). The mixture was stirred at room temperature for 45 min, then concentrated in vacuo to afford the title compound (100 mg).

後処理

  1. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5a9db109a7eb45e9a738bff809330a68
出典データセット
uspto-grants-2010_05
特許番号
US07709503B2

反応ノート

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