1,4-Dioxane hydrochloride → 2-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride

HRID 2233861ノート

反応式

HRID 2233861 の反応式
Cl.O1CCOCC1.[NH2:8][C:9]([C:11]1[CH:16]=[C:15]([Cl:17])[N:14]=[C:13]([N:18]2[CH2:23][CH2:22][CH:21]([NH:24]C(=O)OC(C)(C)C)[CH2:20][CH2:19]2)[CH:12]=1)=[O:10]>>[ClH:17].[NH2:24][CH:21]1[CH2:20][CH2:19][N:18]([C:13]2[CH:12]=[C:11]([CH:16]=[C:15]([Cl:17])[N:14]=2)[C:9]([NH2:8])=[O:10])[CH2:23][CH2:22]1

参加物

3

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86608240tert-Butyl 1-[4-(aminocarbonyl)-6-chloropyridin-2-yl]piperidin-4-ylcarbamate2 回

生成物 1

HCID 866082552-(4-Aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride収率 211.9%

実験手順

4 N HCl/Dioxane solution (6 ml) was added to tert-butyl 1-[4-(aminocarbonyl)-6-chloropyridin-2-yl]piperidin-4-ylcarbamate (Intermediate 16, 100 mg, 0.282 mmol). The mixture was stirred at room temperature for 90 minutes. The solvent was removed in vacuo and the anhydrous diethylether (25 ml) was added. The solvent was removed in vacuo and light yellow solid that resulted was dried under vacuum for several hours to give the title compound as an off-white solid (87 mg).

後処理

  1. customThe solvent was removed in vacuo
  2. additionthe anhydrous diethylether (25 ml) was added
  3. customThe solvent was removed in vacuo and light yellow solid
  4. customthat resulted
  5. customwas dried under vacuum for several hours

出典と根拠

ORDレコード
ord-010a6720b8aa45399fc14b563c0b0bfa
出典データセット
uspto-grants-2010_05
特許番号
US07709503B2

反応ノート

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