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6-Chloro-2-benzothiazolamine → 2-Amino-6-fluorobenzothiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Chloro-2-benzothiazolamine | HCID 7226 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Chlorine | HCID 24526 | — |
| 反応物 | 2,6-Dichlorobenzothiazole | HCID 77176 | — |
| 反応物 | 2-Chloro-6-fluorobenzothiazole | HCID 2049870 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 生成物 | 2-Amino-6-fluorobenzothiazole | HCID 319954 | — |
反応手順
The starting compounds of the formula III wherein X is chlorine or bromine can be prepared from corresponding 2-benzothiazole-amines by reaction with a warm concentrated hydrohalic acid and sodium nitrite [See H. Mazzone and G. Pappalardo, Il Farmaco, Ed. Sc. 32, 348-354 (1977)]. Thus, for example, 2,6-dichlorobenzothiazole (m.p. 99°-101° C.) can be obtained from 6-chloro-2-benzothiazole-amine, and 2-chloro-6-fluorobenzothiazole (m.p. 92°-93° C.) can be obtained from 6-fluoro-2-benzothiazole-amine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04353919 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-b453363a4d5f450080ec690120e5aa05 |
| 出典メモ | uspto-grants-1982_10 |