Methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6-chloroisonicotinate → Methyl 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinate hydrochloride salt
反応式
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:16]=[C:17]([CH:22]=[C:23]([Cl:25])[N:24]=2)[C:18]([O:20][CH3:21])=[O:19])[CH2:11][CH2:10]1)=O)(C)(C)C>Cl.O1CCOCC1>[ClH:25].[NH2:8][CH:9]1[CH2:10][CH2:11][N:12]([C:15]2[CH:16]=[C:17]([CH:22]=[C:23]([Cl:25])[N:24]=2)[C:18]([O:20][CH3:21])=[O:19])[CH2:13][CH2:14]1参加物
3
実験手順
Methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6-chloroisonicotinate (Intermediate 23, 1.81 g, 4.9 mmol) was dissolved in 4 N HCl/dioxane (200 ml). The mixture was stirred at room temperature for 2 h. The solvent was removed under vacuum to give the title compound (1.5 g).
後処理
- customThe solvent was removed under vacuum
出典と根拠
- ORDレコード
- ord-5a28872fc9ec48b28f06254db2780570
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709503B2
反応ノート
読み込み中…