Sulfuryl chloride → Ethyl 2-chloro-4-(2-methoxyethoxy)-3-oxobutanoate
反応式
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][C:7](=[O:14])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10].S(Cl)([Cl:18])(=O)=O>C(Cl)Cl.CCOC(C)=O>[Cl:18][CH:8]([C:7](=[O:14])[CH2:6][O:5][CH2:4][CH2:3][O:2][CH3:1])[C:9]([O:11][CH2:12][CH3:13])=[O:10]参加物
5
実験手順
Ethyl 4-(2-methoxyethoxy)-3-oxobutanoate (Intermediate 123) (0.5 g) was dissolved in anhydrous DCM (5 ml). Sulfuryl chloride (430 mg) was added dropwise at room temperature. The mixture was stirred for 6 h. The crude mixture was diluted with EtOAc (50 ml) and washed well with water and brine, dried over sodium sulfate and concentrated in vacuo to afford the title compound as a light orange oil (414 mg).
後処理
- washwashed well with water and brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-339bde1c8c6b42179d06964ffd5121b5
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709503B2
反応ノート
読み込み中…